Depending on the complexity of your design positioning your Slices wisely could maximize your pages' load time.
First, hit 'Ctrl + R' (key) to make the Horizontal & Vertical Rulers visible. (Alternately - 'View (menu option)/Rulers')
Then, go back to 'View' (menu option) and Select 'Extras' -- This allows you to toggle between any Slices and or (Ruler) Guides on your screen.
Go to 'View' (menu option) again & Select 'Snap'. This will allow for easy click and drag of slices to Snap directly onto your guide. (If you have any laid out?)
With the preliminary preparations out of the way, and you've decided where to lay out your guides, then choose the 'Slice Tool' on the 'Toolbar'.
Click and Drag your first Slice starting at the upper/left portion of your design until you feel it 'Snap' to your (in my case) center guide. Photoshop automatically numbers your 'Slices' in succession.

Sweep across your design until it's completly Sliced. Any areas you do not slice, Photoshop will Auto-Slice it for you.
*** In my case above I,ve Sliced it into a Grid. Two Columns, three Rows. Row One and Row Three are solid colors, so in the final stage I can eliminate these images & replace them with the appropraite html color (in this case -- #5779A0) code.